Projet How social environment modulates tumor progressionJacques MONTAGNE - Université Paris-Saclay, CEA

Instituts associés : INSB, INEE

Description du projet How social environment modulates tumor progression

The social environment is known to affect behavior and fitness of individuals. In humans, physicians often consider that psychological well-being contributes to health recovery, although the underlying physiological mechanisms remain mysterious. Unbiased studies using animal models have often shed light on these types of complex phenomenon. We have shown (Dawson et al., 2018) a link between social environment and progression of a genetically induced intestinal tumor in Drosophila. We plan to decipher the physiological cascade induced by the social context. The working hypothesis is that a chemical signal (pheromone, microbiota ...) acts on the social behavior of sick flies, activating a neurological relay, which in turn modulates a physiological response (immunity, hormones, homeostatis ...) to control tumor progression. The doctoral project will focus on the study of the physiological functions linking social behavior to tumor growth based on differences in transcriptome (RNAseq in progress). This PhD project stems from a collaboration between the Behavior pole (EGCE-UMR9191, INEE,) and the team Growth and Metabolism in Drosophila (I2BC-UMR9198, INSB).

We are looking for a motivated candidate with a sense of teamwork and bases in genetics and cell physiology. Knowledge of the Drosophila model and/or of behavioral analyzes will be positively considered. Candidates should apply through the CNRS site (https://emploi.cnrs.fr/Offres.aspx) and may also directly contact Frederic Marion-Poll (frederic.marion-poll@egce.cnrs-gif.fr) or Jacques Montagne (Jacques.Montagne@i2bc.paris-saclay.fr).

References :
Dawson E, Bailly T, Dos Santos J, Moreno C, Devilliers M, Maroni B, Sueur C ,Casali, A, Ujvari B, Thomas F, Montagne J, Mery F 2018. Social environment mediates cancer progression in Drosophila. Nat Comm, 9, doi: 10.1038/s41467-018-05737-w.
Sueur C, Mery F 2017 . Social Interaction in Animals: Linking Experimental Approach and Social Network Analysis. Frontiers in psychology 8, 35
Garrido D, Rubin T, Poidevin M, Maroni B, LeRouzic A, Parvy JP, Montagne J 2015. Fatty Acid Synthase Cooperates with Glyoxalase 1 to Protect Against Sugar Toxicity. PLoS Genet: 11(2): e1004995.
French AS, Sellier M-J, Ali Agha M, Guigue AMA, Chabaud M-A, Reeb PD, Mitra A, Grau Y, Soustelle L, Marion-Poll F 2015. Dual mechanism for bitter avoidance in Drosophila. J Neurosci 35, 3990-4004.