Optical imaging of brain structure and function on multiple spacial scales
Roscoff (Brittany), France, Junie 11-15, 2014
Deadline for application: March 17, 2014
Chairperson: Angus SILVER
Dept Neuroscience, Physiology & Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
Phone: +44 (0) 207 679 7830 - Fax
Email: a.silver@ucl.ac.uk
Vice-chairperson: Christophe MULLE
CNRS UMR 5297, Université Bordeaux 2, 146, rue Léo-Saignat, 33077 Bordeaux cedex, France
Phone: +33 (0) 5 57 57 40 80 – Fax: +33 (0) 5 57 57 40 82
Email: mulle@u-bordeaux2.fr
This international symposium will bring together leading scientists to present their latest discoveries on synaptic, neuronal and network function and new technological developments for studying the structure and function of the brain. This will foster scientific exchange between neurobiologists and those actively developing new optical methods, connectomics approaches and optogenetic tools. This multidisciplinary interaction will advance our understanding and facilitate new approaches for investigating brain structure and function, both in vitro and in vivo, from the individual molecular components to complex networks in the intact brain. Indeed, advances in understanding brain function critically depend on our capacity to improve the tools available. These advances are particularly important in the field of Neuroscience where challenges in mapping the connections within and between highly complex neuronal networks and measuring signal processing in 3D networks is driving the development of automated electron microscopy, image reconstruction methods and a panoply of new optical methods for measuring and controlling neural activity.
This Jacques-Monod conference is the latest in a series of conferences on studying brain function with optical imaging, ontogenetic approaches and high throughput electron microscopy. The 2014 conference will focus on studying brain function on different spatial scales. At the finest level this will include visualizing individual molecules within synapses and characterizing the properties of spines with super-resolution microscopy in living tissue. At the single cell level the spatial patterns of synaptic inputs on dendritic trees and dendritic integration will be examined with photostimulation, optical imaging and electrophysiology. While at the network level new developments in 3D two-photon imaging are enabling and signalling within neuronal populations to be ‘read out’. New high speed functional measurements will enable us to understand how sensory information is encoded at the synaptic, neuronal and population levels on millisecond time scales. Recent advances in optogenetic methods are complementing these functional imaging methods by allowing the activity of particular cell types to be manipulated, and thus, causal links to be established between neuronal activity and behaviour. There is great excitement about the prospect of mapping the intricate synaptic connectivity in the brain because a detailed knowledge of the wiring diagram will provide new insight and provide a basis for large scale modeling. New connectomics studies showing how complex networks of neurons are connected together will complement our understanding of these functional measurements. Discussion of such a wide range of multidisciplinary approaches will provide a great opportunity to foster new collaborations to undertake novel challenges that will push further our ability to detect, measure, manipulate and follow the intricate components of neuronal and network function, which is key to understanding brain function in health and disease.
This international conference will bring together scientists studying brain function on multiple different scales with physicists and neuroscientists that develop and use new tools. The meeting will cover the following 3 main topics:
• New methods for studying brain structure and function
• Synaptic mechanisms and integration
• Network structure and information processing
Invited speakers
(provisional titles)
AHRENS Misha (Ashburn, USA)
Whole-brain functional imaging and motor learning in the larval zebrafish
BITO Haruhiko (Tokyo, Japan)
Imaging and manipulating active neuronal ensembles
BUREAU Ingrid (Marseille, France)
Mapping the plasticity within neuronal circuits of the somatosensory cortex induced by associative learning
CHARPAK Serge (Paris, France)
Distribution of PO2 in the brain of awake mice
CHOQUET Daniel (Bordeaux, France)
AMPA receptor trafficking and organization in health and disease
COSSART Rosa (Marseille, France)
Large scale imaging of hippocampal network dynamics in the adult awake mouse
DEISSEROTH Karl (Stanford, USA)
Optical deconstruction of fully-assembled biological systems
DIEUDONNé Stéphane (Paris, France)
Optogenetic dissection of the granular layer transfer function
DIGREGORIO David (Paris, France)
Dendritic computations by interneuron dendrites
EMILIANI Valentina (Paris, France)
In vivo patterned optogenetics
HALLERMANN Stefan (Leipzig; Germany)
Presynaptic calcium dynamics at cerebellar mossy fibre boutons.
HÄUSSER Michael (London, UK)
Dendritic computation
HELMSTAEDTER Moritz (Martinsried, Germany)
Connectomics: the dense reconstruction of neuronal circuits
JONAS Peter (Klosterneuburg, Austria)
Signaling in GABAergic interneurons of the hippocampus
KONNERTH Arthur (München, Germany)
Dendritic integration in cortical and hippocampal neurons in vivo
LOSONCZY Attila (New-York, USA)
Functional subdivisions in the GABAergic septohippocampal pathway of behaving mice
MARTY Alain (Paris, France)
Variations in release statistics among single GABAergic synapses reflect variable numbers of vesicular docking sites
MIESENBOCK Gero (Oxford, UK)
Light Sleep
MULLE Christophe (Montpellier, France)
Optophysiological dissection of short-term synaptic plasticity
MRSIC-FLOGEL Thomas (London, UK)
Visual processing in mouse visual cortex
NAGERL Valentin (Bordeaux, France)
Superresolution imaging of synaptic dynamics
NUSSER Zoltan (Budapest, Hungary)
Structure and function of central synapses
SCANZIANI Massimo (La Jolla, USA)
Investigating visual processing with optogenetics
SCHAEFER Andreas (Heidelberg, Germany)
Rapid information processing in the olfactory system
SILVER Angus (London, UK)
Measuring neuronal and network signaling in 3D with Acousto-Optic Lens microscopy
Svoboda Karel (Ashburn, USA)
Imaging the neural circuits underlying active tactile sensation
TAKAHASHI Tomoyuki (Doshisha, Japan)
Imaging vesicle traffics in calyceal presynaptic terminals in culture
WYART Claire (Paris, France)
Dissection of spinal circuits underlying locomotion
YASUDA Ryohei (Jupiter, USA)
Imaging signal transduction in single dendritic spines
Deadline for application: March 17, 2014
Registration fee (including board and lodging)
400 € for PhD students
650 € for other participants
Some fellowships will be available for student and post-doc
Application for registration
The total number of participants is limited to 115 and all participants are expected to attend for the whole duration of the conference. Selection is made on the basis of the affinity of potential participants with the topics of the conference. Scientists and PhD Students interested in the meeting should send:
- their curriculum vitae
- the list of their main publications for the 3 last years
- the abstract of their presentation
to the Chairperson of the conference (a.silver@ucl.ac.uk) before the deadline. After it, the organizers will select the participants. Except in some particular cases approved by the Chairperson, it is recommended that all selected participants present their work during the conference, either in poster form or by a brief in- session talk. The organizers choose the form in which the presentations are made. No payment will be sent with application. Information on how and when to pay will be mailed in due time to those selected.