Sept scientifiques de CNRS Biologie élus membres de l'EMBO

Stem cell regulation and tissue homeostasis

Our group aims to elucidate cell-intrinsic and cell-extrinsic processes controlling stem cell fate and genome stability. Ultimately, we would like to understand the control mechanisms that allow stem cells to promote tissue homeostasis in young, healthy contexts and how these become defective during aging or disease. We combine genetic approaches with genomics and imaging techniques in Drosophila to define conserved mechanisms of stem cell biology.

Génétique et biologie du développement
CNRS/Inserm/Institut Curie

Yeast meiotic and somatic homologous recombination

My lab studies how cells repair the double-strand breaks deliberately induced during meiosis, by homologous recombination. This step is essential for the accurate segregation of homologous chromosomes, and therefore for obtaining gametes (eggs or sperm) with a normal chromosome content, preventing aneuploidy at the source of chromosomal diseases or infertility.

Dynamique de l'information génétique : bases fondamentales et cancer
CNRS/Institut Curie/Sorbonne Université

Molecular mechanisms of cell division

Our lab studies cytokinesis, the final step of cell division that leads to the physical separation of daughter cells. Our aim is to discover new molecular mechanisms involved in cytokinetic abscission in eukaryotic cells and to uncover unexpected parallels between cell division and viral budding. We are particularly interested in understanding the membrane and cytoskeletal remodeling steps that are essential for these two topologically related processes.

Dynamique cellulaire physiologique et pathologique
CNRS/Institut Pasteur

Glia and macrophages in immunity and beyond

My laboratory focuses on the molecular and epigenetic mechanisms regulating the development and role of Drosophila glia and macrophages. These cells are involved in the immune response and also control tissue homeostasis by sensing and responding to the environment. Assessing how these mechanisms are evolutionarily conserved allows us to understand the biology of cells that play key roles in development and physiology.

Institut de génétique et de biologie moléculaire et cellulaire
CNRS/Inserm/Université de Strasbourg

Functions of mechanical signals in plants

My group is working on the role of mechanical signals in plant development. Our research also sheds a new light on the question of robustness of living organisms. In the frame of the Michel Serres Institute, I contribute to several projects in the fields of art, science and education around the existential issues of the Anthropocene.

Reproduction et développement des plantes
CNRS/ENS de Lyon/Inrae

Cellular responses to replication stress

My lab investigates the origin and the consequences of replication stress in yeast and human cells using a combination of single-molecule imaging and genome-wide approaches. Our main research interests include transcription-replication conflicts and R-loops, fork remodeling by SMC complexes, checkpoint signaling, and activation of the innate immune response by cytosolic DNA released from stressed replication forks.

Institut de génétique humaine
CNRS/Université de Montpellier

Plant hormones and shoot development dynamics

My group explores how self-organization enables robust dynamic development in plants. To do so, we study how hormones drive the dynamics of rhythmic morphogenesis at the shoot apex. We use interdisciplinary approaches, ranging from quantitative live imaging, biosensor development, functional genomics and structural biology to modelling, in order to unravel how these developmental signals act across scales to build a robust shoot architecture.

Reproduction et développement des plantes
CNRS/ENS de Lyon/Inrae