Molecular basis for membrane remodelling and organization

20 novembre 2018

Roscoff (Brittany), France, September 24-28, 2011

Deadline for application: May 15, 2011

Chairperson: Harvey T McMAHON

MRC Laboratory of Molecular Biology, Neurobiology Division, Hills Road, Cambridge CB2 0QH, UK
Phone: +44 1223 402311 – Fax: +44 1223 402310
Mail: hmm@mrc-lmb.cam.ac.uk

Vice-Chairperson: Barbara WINSOR

Département de Biologie moléculaire et cellulaire, UMR7156 CNRS - Université de Strasbourg,
21 rue Descartes, 67084 Strasbourg cedex, France
Phone: 33 3 68 85 14 70 – Fax: 33 3 88 41 70 70
Mail: b.winsor@unistra.fr

Membranes are dynamic and direct players in cell physiology, organelle structure and biogenesis, membrane transport and intracellular traffic and in dysfunctions leading to disease such as Alzheimer’s disease, chronic inflammation, viral infections and metastatic cell invasion. While membranes allow for compartmentalisation of many different processes in the cell and thus allow for complexity, these compartments are dynamic and constantly interchanging components.

This conference focuses on a particular aspect of membrane dynamics - that of their shape and its consequences. Different cell types can often be recognised by their shape. Likewise, different organelles can be recognised by their different shapes (morphologies), have different lipid and protein compositions and associated function. Even within an individual membrane there are many subdomains, which can be scaffolded by proteins, by localized lipid compositions, by membrane curvature or by a combination thereof. Different lipid compositions of membranes have been recognised for some time, but the significance of different local curvatures is only beginning to be appreciated. This conference seeks to draw together scientists from various communities who are interested in membrane dynamics to present recent results and put ideas together on how membrane curvature is controlled and how it in turn, influences cellular processes.

The conference is structured around several topics:

Membrane curvature in vesicle fusion
Membrane curvature in endocytosis and vesicle budding
Actin and endocytosis
Shaping organelles
Shaping organisms
Molecular modules that influence membrane curvature
Virus budding and fusion
Membrane dynamics and disease

Invited speakers

ANTONNY Bruno (Valbonne, France)
ALPS Motifs and alpha-synuclein: the Yin-Yang of membrane curvature sensors

ASPENSTRÖM Pontus (Stockholm, Sweden)
Rho GTPases in the regulation of membrane trafficking

BASSEREAU Patricia (Paris, France)
Studying membrane curvature in cell trafficking with membrane nanotubes

CARLIER Marie-France (Gif-sur-Yvette, France)
Coupled dynamics of actin filaments and membranes in motile processes: a reconstitution approach

CHERNOMORDIK Leonid (Bethesda, USA)
Fusion in development and in viral entry

DARCHEN François (Paris, France)
Regulation of fusion pore dynamics during exocytosis

DE CAMILLI Pietro (Yale, USA)
Vesicle formation in nerve terminals

GEYER Matthias (Dortmund, Germany)
Assembly of formin actin nucleation factors at the plasma membrane

GOUD Bruno (Paris, France)
Mechanisms of intracellular transport in eukaryotic cells: from physics to...biology

GRASSART Alexandre (Berkeley, USA)
Systematic siRNA-based analysis of endocytic protein function by dual-colour real-time imaging in genome edited cells

KOZLOV Misha (Tel Aviv, Israel) To be confirmed/participation à confirmer
Modelling membrane shaping by proteins

LANGEN Ralf (Los Angeles, USA)
Molecular mechanisms of membrane curvature induction

LAPPALAINEN Pekka (Helsinki, Finland)
Regulation of plasma membrane and actin dynamics by I-BAR domain proteins

LENNE Pierre-Francois (Marseille, France)
Force generation and cell shape changes during tissue morphogenesis

MERESSE Stéphane (Marseille, France)
Manipulation of host cell membranes by Salmonella effector proteins

PERRAIS David (Bordeaux, France)
Assessing the molecular dynamics of clathrin-mediated endocytosis using quantitative live-cell imaging

PETIT Christine (Paris, France)
Title to be coming

RAPOPORT Tom (Boston, USA)
How the ER gets into shape

REY Félix (Gif-sur-Yvette, France)
Enlarging the repertoire of class II viral membrane fusion proteins

ROEMER Winfried (Freibourg, Germany)
Synthetic membrane biology: Reconstitution of cellular processes on artificial membrane systems

ROTHMAN James (New Haven, USA)
Membrane fusion

SCITA Giorgio (Milan, Italy)
Membrane and actin dynamic interplay in the plasticity of tumor cell migration

STAMOU Dimitrios (Copenhagen, Denmark)
Three distinct pathways by which curvature modulates the structure and function of membranes

STANLEY Richard (New York, USA)
The F-BAR protein, PSTPIP2, mediates membrane-cytoskeletal interactions in macrophage and osteoclast development and function

SUETSUGU Shiro (Tokyo, Japan)
The BAR domain proteins involved in caveola morphogenesis

WEISSENHORN Winfried (Grenoble, France)
Membrane remodelling by ESCRTs

ZIMMERBERG Joshua (Bethesda, USA)
Lipids and proteins that determine shape and catalyse topological transformations

Deadline for application: May 15, 2011

Registration fee (including board and lodging)

390 € for PhD students
530 € for other participants

Application for registration

The total number of participants is limited to 115 and all participants are expected to attend for the whole duration of the conference. Selection is made on the basis of the affinity of potential participants with the topics of the conference. Scientists and PhD Students interested in the meeting should send:

their curriculum vitae
the list of their main publications for the 3 last years
the abstract of their presentation

to the Chairperson of the conference before the deadline. Applicants will be notified regarding their participation by June 1rst. Except in particular cases approved by the Chairperson, it is recommended that all selected participants present their work during the conference, either in poster form or by a brief in-session talk. The organizers choose the form in which the presentations are made. No payment should be sent with the application. Information on how and when to pay will be mailed in due time to those selected.