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RNA at the center of gene regulation

Roscoff (Brittany), France, April 4-8, 2009

 

Deadline for application: January 30, 2009

 

Chairperson: Gerhart Wagner

Department of Cell and Molecular Biology, Microbiology Program, Biomedical Center,
Uppsala University, Box 596, S-751 24, Uppsala, Sweden
Phone: +46 18 4714866 - Fax: +46 18 530396
Mail: gerhart.wagner@icm.uu.se

 

Vice-Chairperson: Anne-Catherine Prats

Unité mixte INSERM U858, Institut de Médecine Moléculaire de Rangueil, IFR31,
Avenue Jean Poulhès, BP 84225, 31432 Toulouse cedex 4, France
Phone: + 33 5 61 32 56 02 – Fax: +33 5 61 32 56 22
Mail: pratsac@toulouse.inserm.fr

 

RNA molecules are key players in numerous regulatory processes in all kingdoms of life. The Nobel Prize, awarded to Fire and Mello in 2006 for the discovery of RNA interference, testifies to the timeliness of research in this field. Small RNAs inhibit or activate genes by interacting with mRNAs, in pro- as well as eukaryotes. This occurs by different molecular mechanisms and affects many cellular processes - from stress responses, metabolism, development, maintenance of genome integrity, and defense against invaders. In addition to the plethora of trans-acting small RNAs in bacteria, and miRNAs, siRNAs, piRNAs and others in eukaryotes, many structural elements within mRNAs promote regulation or are the sites at which regulation is exerted. Gene expression is also affected by RNA turnover, and by various quality control mechanisms that ensure that mRNAs encode proper proteins. More and more links between RNAs and epigenetic phenomena are emerging and impact on our understanding of diseases. In the past few years, the range of subjects covered by this Jacques Monod Conference have spawned fascinating and important discoveries in these areas.

The Conference "RNA at the center of gene regulation" is aimed at covering the most recent exciting developments in this field. The work presented and discussed by the selected speakers addresses biological roles and mechanisms of RNA-mediated control processes. The conference is structured in several topics:

  • RNA metabolism, turnover, and transport
    • A) degradation and control
    • B) localization and transport
  • RNA quality control
  • Gene silencing / epigenetics
  • miRNA mechanisms
  • Bacterial regulatory RNAs
    • A) sRNA function and mechanisms
    • B) Defense mechanisms against viruses
  • Post-transcriptional regulation
    • A) snRNPs
    • B) Translation

 

Invited speakers

(provisional titles)

 

BELASCO Joël (New-York, USA)
Control of bacterial mRNA degradation

BRANLANT Christiane (Vandoeuvre-lès-Nancy, France)
Assembly pathways of RNP particles in eukarya

CACERES Javier (Edinburgh, UK)
Auxiliary factors for microRNA processing

CONDON Ciarán (Paris, France)
RNA maturation and decay in Bacillus subtilis

COSSART Pascale (Paris, France)
NcRNAs in the pathogen Listeria monocytogenes

HEARD Edith (Paris, France)
Non-coding RNAs in X-chromosome inactivation

HENTZE Mathias (Heidelberg, Germany)
Translational control by miRNAs and RNA-binding proteins

HORVATH Philippe (Dangé-Saint-Romain, France)
CRISPR, a new phage resistance system in prokaryotes

KETTING René (Utrecht, Netherlands)
Small RNAs in animal germ cells

KISS Tamas (Toulouse, France)
Small nuclear RNAs in regulation of gene expression

LÖTVALL Jan (Göteborg, Sweden)
Exosomal shuttle of RNAs

LUND Anders (Copenhagen, Denmark)
New functions of microRNA

LUNDGREEN Magnus (Wageningen, Netherlands)
CRISPR RNAs guide in antiviral defense

MAQUAT Lynne (Rochester, USA)
Nonsense-Mediated and Staufen1-Mediated mRNA Decay

MARTINEZ Javier (Vienna, Austria)
Post-transcriptional regulation of microRNA expression

MOORE Melissa (Worcester, USA)
RNA quality control

MOURELATOS Zissimos (Philadelphia, USA)
piRNAs and piRNPs

PARKER Roy (Tucson, USA)
Control of translation and mRNA degradation in yeast

PAZ-ARES Javier (Madrid, Spain)
Target mimicry: regulation of microRNA activity

PRATS Anne-Catherine (Toulouse, France)
Regulation of fibroblast growth factor 1 expression during myogenesis

SELMER Maria (Uppsala, Sweden)
Structural studies of ribosomal frameshifting

SERAPHIN Bertrand (Gif sur Yvette, France)
Regulation of mRNA decay

SIOMI Mikiko (Tokyo, Japan)
Molecular mechanisms of RNA silencing in Drosophila

TOMASETTO Catherine (Illkirch, france)
Beast cancer protein MLN51 functions in mRNA metabolism

VOGEL Jörg (Berlin, Germany)
Multiple target regulation by Salmonella small RNAs

VOINNET Olivier (Strasbourg, France)
Small RNA pathways and their interference by pathogens in eukaryotes

 

 

Deadline for application: January 30, 2009

 

Registration fee (including board and lodging)

360 € for PhD students
570 € for other participants

 

Application for registration

The total number of participants is limited to about 115 and all participants are expected to attend for the whole duration of the conference. Selection is made on the basis of the affinity of potential participants with the topics of the conference. Scientists and PhD Students interested in the meeting should send:

  • their curriculum vitae
  • the list of their main publications for the 3 last years
  • the abstract of their presentation

 

to the Chairperson of the conference before the deadline. After it, the chairman will select the participants. Except in some particular cases approved by the Chairperson, it is recommended that all selected participants present their work during the conference, either in poster form or by a brief in- session talk. The organizers choose the form in which the presentations are made. No payment will be sent with application. Information on how and when to pay will be mailed in due time to those selected.