Cell division: from single molecule mechanics to multicellular organisms
Roscoff (Brittany), France, September 5-9, 2012
Deadline for application: May 20, 2012
Chairperson: Ariane ABRIEU
CRBM – CNRS UMR 5237, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
Phone: (33) 4 34 35 95 52/54 - Fax: (33) 4 34 35 94 10
Mail: ariane.abrieu@crbm.cnrs.fr
Vice-Chairperson: Andrea MUSACCHIO
Max-Planck Institute of Molecular Physiology Otto-Hahn-Str. 11 44227 Dortmund, Germany
Phone: +49 231 133 2101 - Fax : +49 231 133 2199
Mail : andrea.musacchio@mpi-dortmund.mpg.de
Cell cycle research today is sustained through crucial technological advances, most notably in the area of imaging but also in the area of very high-resolution analyses of biological specimens. The technological exploitation of fluorescent proteins revolutionized the way one can now study cell cycle genes. Besides allowing studies on the localization and cellular dynamics of cell cycle gene products, this approach is currently supporting the explosion of single molecule studies. Coupled with in vitro reconstitution approaches, for instance, these studies have recently led to the reconstitution of multi-component protein systems capable of establishing stable steady-state driven by ATP consumption in vitro. In the meantime, genetic tools to study cell cycle genes in multicellular organisms considerably improved. This allows drawing an integrated picture of the role of cell cycle genes during development, growth and cancer. Chemical genetics is very favorably influencing our way of carrying out experiments in the short timeframe of cell cycle events, such as mitosis, without interfering with other cell cycle phases, and therefore achieving much more accurate phenotypic consequences.
The purpose of this conference is to bring together scientists fascinated by cell division, but who approach the problem from different perspectives due to their different backgrounds and expertise. This requires the contribution of physicists, which keep developing new techniques to dissect the mechanics of enzymes, biochemists and structural biologists, who are in the midst of reconstituting complex cell cycle multi-protein modules, chemists who are developing more and more specific inhibitors of key enzymes such as molecular motors and kinases, physiologists who are starting to describe how cell cycle gene perturbations affect certain tissues, and medical doctors who are exploring how cell cycle perturbations promote cancer.
Invited speakers
(provisional titles)
ABRIEU Ariane (Montpellier, France)
Mitosis: to split or to die
BARFORD David (London, United Kingdom)
Structural analysis of APC/C assembly and degron recognition
BARRAL Yves (Zürich, Switzerland)
Coordination of cytoskeletal events during mitosis
BASTO Renata (Paris, France)
Investigating the contribution of centrosome amplification to aneuploidy and tumourigenesis
CHEESEMAN Iain (Cambridge, USA)
Building a dynamic kinetochore-microtubule interface
CLEVELAND Don (La Jolla, USA)
Catalytic generation of the mitotic checkpoint inhibitor that blocks ubiquitination and degradation of cyclin B
ELLENBERG Jan (Heidelberg, Germany)
Multipolar spindle assembly and error-prone chromosome bi-orientation in the first meiotic division of mouse oocytes
GLOTZER Michael (Chicago, USA)
Control of cortical contractility during cytokinesis
GONZALEZ Cayetano (Barcelona, Spain)
The contribution of germline proteins to somatic cancer
HIROTA Toru (Tokyo, Japan)
How abruptness of chromosome segregation is ensured in mammalian cells
HYMAN Tony (Dresden, Germany)
Mesoscale organization of cytoplasm during the cell cycle
JALEPALLI Prasad (New York, USA)
Making and breaking the 'wait anaphase' signal
JAVERZAT Jean-Paul (Bordeaux, France)
The establishment of sister-chromatid cohesion in fission yeast
KARESS Roger (Paris, France)
RZZ and the Kinetochore
LORCA Thierry (Montpellier, France)
How Greatwall and its substrates control the cell cycle
MALUMBRES Marco (Madrid, Spain)
Genetic analysis of mammalian mitotic kinases
McAINSH Andrew (Coventry, United Kingdom)
How to power chromosome movement
MEIJER Laurent (Roscoff, France)
Pharmacological inhibitors of CDKs: convergence of effects on the MYC pathway
MUSACCHIO Andrea (Dortmund, Germany)
Molecular basis of chromosome segregation
PELLMAN David (Boston, USA)
DNA Breaks and Chromosome Pulverization from errors in mitosis
PIATTI Simonetta (Montpellier, France)
Septin dynamics in the control of budding yeast mitotic exit and cytokinesis
PIEL Matthieu (Paris, France)
Forces and Cell Division
PINES Jon (Cambridge, United Kingdom)
How the Spindle Assembly Checkpoint regulates the APC/C
STUKENBERG Todd (Charlottesville, USA)
Mitotic regulation of kinetochores
SURREY Thomas (Londres, United Kingdom)
The structural basis of microtubule plus end tracking
TAYLOR Stephen (Manchester, United Kingdom)
Switching on and off the spindle checkpoint
VERLHAC Marie-Hélène (Paris, France)
Control of asymmetric divisions in acentriolar meiosis
WASSMANN Katja (Paris, France)
Correct chromosome segregation in mouse oocyte meiosis
Deadline for application: May 20, 2012
Registration fee (including board and lodging)
400 € for PhD students
650 € for other participants
Application for registration
The total number of participants is limited to 115 and all participants are expected to attend for the whole duration of the conference. Selection is made on the basis of the affinity of potential participants with the topics of the conference. Scientists and PhD Students interested in the meeting should send:
- their curriculum vitae
- the list of their main publications for the 3 last years
- the abstract of their presentation
to the Chairperson of the conference (ariane.abrieu@crbm.cnrs.fr) before the deadline. After it, the chairman will select the participants. Except in some particular cases approved by the Chairperson, it is recommended that all selected participants present their work during the conference, either in poster form or by a brief in- session talk. The organizers choose the form in which the presentations are made. No payment will be sent with application. Information on how and when to pay will be mailed in due time to those selected.