Actin and microtubule cytoskeleton in cell motility and morphogenesis: An integrated view

Roscoff (Brittany), France, May 26-30, 2015

 

Deadline for application: February 20, 2015

 

Chairperson: Marie-France CARLIER

Groupe Dynamique du cytosquelette et motilité cellulaire, LEBS - UPR 3082, 1 avenue de la Terrasse,
91198 Gif-sur-Yvette cedex, France
Phone: +33 (0) 1 69 82 34 65
Email: carlier@lebs.cnrs-gif.fr

 

Vice-chairperson: Thomas SURREY

The Francis Crick Institute, Lincoln's Inn Fields Laboratory, 44 Lincoln’s Inn Fields, London WC2A 3LY, United Kingdom
Phone: +44 20 7269 3336
Email : thomas.surrey@crick.ac.uk

 

Actin filaments and microtubules are the major cytoskeletal polymers that undergo self-assembly and disassembly in a coordinated fashion to polarize cells for directional migration, division, and other vectorial morphogenetic processes in eukaryotic cells. Ancestor proteins related to actin and tubulin similarly coordinate cellular functions in bacteria. How is the functional interaction between these polymers established and maintained is a major unanswered question in biology. The goal of this Jacques Monod Conference is to bring the different cytoskeleton fields together. For many years, identification of the players and regulators has dominated both fields. Now comes the time for understanding molecular mechanisms that support biochemical function and macroscopic mechanical properties using advanced imaging, in vitro reconstructions and mathematical modelling. Researchers of complementary expertise will address how self-organized cellular systems emerge, and eventually how defects leading to disease and cancer arise.
 

Invited speakers
(provisional titles)

 

AKHMANOVA Anna (University of Utrecht, Netherlands)
Regulation of cell architecture by microtubule end-binding proteins

BAUM Buzz (University College London, London, United Kingdom)
Crosstalk between actin and microtubule polymers

BERSHADSKY Alexander (Weizmann Institute, Rehovot, Israel)
Local organization and dynamics of actin networks

BLANCHOIN Laurent (Commissariat à l’Energie Atomique, Grenoble, France)
Spatial control of actin networks using micropatterns

CARBALLIDO-LOPEZ Rut (INRA, Jouy en Josas, France)
Functions of bacterial actins

CHANG Fred (Columbia University, New York, USA)
Role of the contractile ring in fission yeast cytokinesis

CHARRAS Guillaume (University College London, London, United Kingdom)
Mechanisms of leading edge protrusion in interstitial migration of neutrophils

DOGIC Zvonimir (Brandeis University, Boston, USA)
Collective properties of active microtubule gels

ETIENNE-MANNEVILLE Sandrine (Institut Pasteur, Paris, France)
Cytoskeletal crosstalk during cell migration

GELLES Jeff (Brandeis University, Boston MA, USA)
Mechanisms of actin network regulation revealed by multi-wavelength single molecule fluorescence microscopy

GUEROUI Zoher (Ecole Normale Supérieure, Paris, France)
Spatial control of cytoskeletal assemblies using magnetic nanoparticles

HAMMER John (National Institute of Health, Bethesda, USA)
Capping Protein Regulation in Vitro and in Vivo

JANKE Carsten (Institut Curie, Orsay, France)
Tubulin modifying enzymes in organism development

KAPOOR Tarun (Rockefeller University, New York, USA)
Nucleation of microtubules by augmin

KOENDERINK Gijsje (AMOLF, Amsterdam, Netherlands)
Actin-microtubule coordination at growing microtubule ends

KOVAR David (University of Chicago, Chicago, USA)
Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex

LIPPINCOTT-SCHWARTZ Jennifer (National Institute of Health, Bethesda, USA)
Contractile and adhesive forces in cell crawling

LÖWE Jan (MRC, LMB-Cambridge, Cambridge, United Kingdom)
Assemblies of bacterial cytoskeleton

MERRIFIELD Christian (Laboratoire d'Enzymologie et Biochimie Structurales, Gif-sur-Yvette, France)
Kinetics of scission events in endocytosis

MINC Nicolas (Institut Jacques Monod, Paris, France)
Developmental Morphogenesis of a Single Cell

MITCHISON Timothy (Harvard Medical School, Boston, USA)
Keynote lecture 1(TBA) – supported by the Company of Biologists

MULLINS Dyche (University of California San Francisco, San Francisco, USA)
Actin in the nucleus ?

NEDELEC François (EMBL, Heidelberg, Germany)
Integrated models of actin and microtubules driven morphogenetic processes

NOGALES Eva (University of California at Berkeley, Berkeley, USA)
Structural basis of microtubule dynamic instability and its regulation

PAOLETTI Anne (Institut Curie, Paris, France)
Spatio-temporal control of cell division in fission yeast by Pom1 and Cdr2 kinases

PIEL Mathieu (Institut Curie, Paris, France)
Spontaneous polarization and fast amoeboid like migration of non-adhesive mesenchymal cells under confinement

ROMET- LEMONNE Guillaume (Laboratoire d'Enzymologie et Biochimie Structurales, Gif-sur-Yvette, France)
Single filament assembly dynamics using microfluidics-assisted TIRF microscopy

ROTTNER Klemens (Technische Universität Braunschweig, Braunschweig, Germany)
Functional interactions between actin filaments and microtubules in podosomes

SMALL Vic (Institute of Molecular biotechnology, Vienne, Austria)
Keynote Lecture 2- supported by EMBO

WATANABE Naoki (Kobe University, Kobe, Japan)
Single molecule analysis of the control of actin assembly in vitro and in vivo 

WAY Michael (London Research Institute, London, United Kingdom)
Control of Arp2/3 dependent actin based motile processes

 

Deadline for application: February 20, 2015

 

Registration fee (including board and lodging)

450 € for PhD students
650 € for other participants

 

Application for registration
The total number of participants is limited to 115 and all participants are expected to attend for the whole duration of the conference. Selection is made on the basis of the affinity of potential participants with the topics of the conference. Scientists and PhD Students interested in the meeting should send:

- their curriculum vitae
- the list of their main publications for the 3 last years
- the abstract of their presentation

to the Chairperson of the conference (carlier@lebs.cnrs-gif.fr) before the deadline. After it, the organizers will select the participants. Except in some particular cases approved by the Chairperson, it is recommended that all selected participants present their work during the conference, either in poster form or by a brief in- session talk. The organizers choose the form in which the presentations are made. No payment will be sent with application. Information on how and when to pay will be mailed in due time to those selected.