"DIVERSITY OF BIOLOGICAL MECHANISMS" 2021- Appel à projets de l'INSB
Since life has appeared on earth, it has developed into a great diversity of forms as the result of adaption and evolution. This diversity still remains to be described and understood since most of the species are largely unknown both on land and in the oceans. Investigating this biological diversity will be essential for understanding life history and evolution. Despite or because this incredible diversity, most biologists have focused their studies to a limited number of models which have been very powerful to learn a lot about biological mechanisms from viruses to humans. With the progress of DNA sequencing and manipulation coupled to new technologies for growing and imaging non-standard species, it is timely to develop and characterize new micro- and macro- models such as viruses, bacteria, archaea, protists and multicellular organisms to answer important questions in biology and evolution such as eukaryote, plant and animal origins. Investigating this diversity of biological mechanisms will also allow to identify new molecular pathways and enzymes or products which might benefit to industry or medicine.
This is why the Institute for Biological Sciences (INSB) at CNRS is launching for the second year a call that aims at developing studies on so far non-canonical biological models and mechanisms. In particular, studies to identify and/or develop new models to answer important and specific biological questions that cannot be addressed in the currently available model organisms will be strongly favored.
Projects from laboratories primary affiliated to INSB will be funded for two years with a budget up to 20 k€ per year. Budget should be dedicated to running costs, equipment strictly necessary for the project. Genome and transcriptome sequencing are eligible if required and justified. No salary or student allowance will be granted. Projects will be evaluated on their originality and the strong adequacy between the biological question and the models to be identified or developed. Original projects using longstanding models will not be eligible to this call. In addition, the applicants should benefit of the proper intellectual and technical environment to develop their project and collaboration are welcome if necessary i (in such cases travel and meeting expenses to establish or strengthen collaborations will be eligible). Since identifying and developing new models can take several years, selected projects will be able to reapply after the first two years, providing significant progresses.
Applications of 5 pages plus a CV of 2 pages (7 pages maximum in total including figures) should follow the following organization:
Applicant NAME DBM2021.pdf
1) State of the art of the biological question
2) Rationale for the identification or the choice of the model(s)
3) Experimental plan
5) Milestones and planned achievements
6) Work forces, infrastructures available and annual budget
7) Validation by the unit director
The deadline is February 5th, 2021 at 12am, Paris hour.
Applicants will have to send their application as a single pdf to the following address: firstname.lastname@example.org
Selected projects will be announced by middle March 2021.
i: in case of collaborations, the budget will be attributed to the applicant’s laboratory.
The winning projects are :
PUFAlg : Microalgal Poly-Unsaturated Fatty-Acid Signalling and Structuring Functions, Corellou Florence, Bordeaux
Deployment of the crinoid Antedon mediterranea as a new model to assess deuterostome nervous system evolution. Croce Jenifer, Villefranche-sur-Mer
Ascidian Diversity: increasing the number of ascidian species for experimental comparative developmental biology, Darras Sébastien, Banyuls sur Mer
Unraveling regeneration success in emerging annelid model species through a single-cell approach, Gazave Eve, Paris
The jellyfish Clytia hemisphaerica as a novel model system to explore meiosis diversity and evolution, Huynh Jean-René, Paris
Impact of non-canonical centromeres on genome architecture, Muller Héloïse, Paris
Non-canonical regulation of non-coding RNA in an unconventional marine algal-virus interaction where the enzymes AGO and DICER are absent, Piganeau Gwenaëlle, Banyuls-sur-Mer
Unraveling evolutionary determinants of plant terrestrialization through the development of streptophyte algal models, Renault Hugues, Strasbourg + TERRESTRIALIZATION: A model to understand how plants crawled out of water, Delaux Pierre-Marc, Toulouse – porteurs invités à joindre leurs efforts
Development of Nymphaea thermarum as the first functional-genetic model basal angiosperm for studies of the origin of flowers, Scutt Charlie, Lyon
Different strategies for evolving "intelligence" in vertebrates: studying neural basis of higher-order cognitions in teleost fish, Yamamoto Kei, Saclay. Projet différé à 2021.